Then the Lord will make thy plagues wonderful,.... Visible, remarkable, distinguishable, and astonishing to all that see them:

and the plagues of thy seed; for they were to continue, as they have done, With their posterity, age after age:

even great plagues, and of long continuance; great as to quality and quantity, and firm, sure, lasting, and durable; the word used is rendered "sure" in Isaiah 55:3; sure by prophecy and in the event; and which when inflicted remained, as they have 1700 years; all which might be believed as certain, or what would certainly come to pass, and be depended on:

and sore sicknesses, and of long continuance; besides those diseases mentioned Deuteronomy 28:27; or however others including them.

If Israel should not do this, the Lord would make its strokes and the strokes of its seed wonderful, i.e., would visit the people and their descendants with extraordinary strokes, with great and lasting strokes, and with evil and lasting diseases (Deuteronomy 28:60), and would bring all the pestilences of Egypt upon it. השׁיב, to turn back, inasmuch as Israel was set free from them by the deliverance out of Egypt. מדוה is construed with the plural as a collective noun.

Then the LORD will make thy plagues wonderful, and the plagues of thy seed, even great plagues, and of long continuance, and sore sicknesses, and of long continuance.

28:45-68 If God inflicts vengeance, what miseries his curse can bring upon mankind, even in this present world! Yet these are but the beginning of sorrows to those under the curse of God. What then will be the misery of that world where their worm dieth not, and their fire is not quenched! Observe what is here said of the wrath of God, which should come and remain upon the Israelites for their sins. It is amazing to think that a people so long the favourites of Heaven, should be so cast off; and yet that a people so scattered in all nations should be kept distinct, and not mixed with others. If they would not serve God with cheerfulness, they should be compelled to serve their enemies. We may justly expect from God, that if we do not fear his fearful name, we shall feel his fearful plagues; for one way or other God will be feared. The destruction threatened is described. They have, indeed, been plucked from off the land, ver. 63. Not only by the Babylonish captivity, and when Jerusalem was destroyed by the Romans; but afterwards, when they were forbidden to set foot in Jerusalem. They should have no rest; no rest of body, ver. 65, but be continually on the remove, either in hope of gain, or fear of persecution. No rest of the mind, which is much worse. They have been banished from city to city, from country to country; recalled, and banished again. These events, compared with the favour shown to Israel in ancient times, and with the prophecies about them, should not only excite astonishment, but turn unto us for a testimony, assuring us of the truth of Scripture. And when the other prophecies of their conversion to Christ shall come to pass, the whole will be a sign and a wonder to all the nations of the earth, and the forerunner of a general spread of true christianity. The fulfilling of these prophecies upon the Jewish nation, delivered more than three thousand years ago, shows that Moses spake by the Spirit of God; who not only foresees the ruin of sinners, but warns of it, that they may prevent it by a true and timely repentance, or else be left without excuse. And let us be thankful that Christ hath redeemed us from the curse of the law, by being made a curse for us, and bearing in his own person all that punishment which our sins merit, and which we must otherwise have endured for ever. To this Refuge and salvation let sinners flee; therein let believers rejoice, and serve their reconciled God with gladness of heart, for the abundance of his spiritual blessings.