And God Almighty bless thee, and make thee fruitful, and multiply thee, that thou mayest be a multitude of people;

Wesley's Notes

28:3-4 Two great promises Abraham was blessed with, and Isaac here entails them both upon Jacob. The promise of heirs, God make thee fruitful and multiply thee. Through his loins that people should descend from Abraham which should be numerous as the stars of heaven. Through his loins should descend from Abraham that person in whom all the families of the earth should be blessed. The promise of an inheritance for those heirs, Ge 28:4. That thou mayest inherit the land of thy sojournings - (So the Hebrew) Canaan was hereby entailed upon the seed of Jacob, exclusive of the seed of Esau. Isaac was now sending Jacob away into a distant country to settle there for some time; and lest this should look like disinheriting him, he here confirms the settlement of it upon him. This promise looks as high as heaven, of which Canaan was a type. That was the better country which Jacob, with the other patriarchs, had in his eye when he confessed himself a stranger and pilgrim on the earth, Heb 11:16.

King James Translators' Notes

a multitude...: Heb. an assembly of people

Matthew Henry's Concise Commentary

28:1-5 Jacob had blessings promised both as to this world and that which is to come; yet goes out to a hard service. This corrected him for the fraud on his father. The blessing shall be conferred on him, yet he shall smart for the indirect course taken to obtain it. Jacob is dismissed by his father with a solemn charge. He must not take a wife of the daughters of Canaan: those who profess religion, should not marry with those that care not for religion. Also with a solemn blessing. Isaac had before blessed him unwittingly; now he does it designedly. This blessing is more full than the former; it is a gospel blessing. This promise looks as high as heaven, of which Canaan was a type. That was the better country which Jacob and the other patriarchs had in view.