Even by the God of thy father, who shall help thee; and by the Almighty, who shall bless thee with blessings of heaven above, blessings of the deep that lieth under, blessings of the breasts, and of the womb:

Wesley's Notes

49:25 Even by the God of thy father Jacob, who shall help thee - Our experiences of God's power and goodness in strengthning us hitherto, are encouragements still to hope for help from him. He that has helped us, will. And by the Almighty, who shall bless thee; and he only blesseth indeed. Observe the blessings conferred on Joseph; First, Various and abundant blessings. Blessings of heaven above, rain in its season, and fair weather in its season; blessings of the deep that lies under this earth, or with subterraneous mines and springs. Blessings of the womb and the breasts are given when children are safely born and comfortably nursed. Secondly, Eminent and transcendent blessings, which prevail above the blessings of my progenitors - His father Isaac had but one blessing, and when he had given that to Jacob, he was at a loss for a blessing to bestow upon Esau; but Jacob had a blessing for each of his twelve sons, and now at the latter end, a copious one for Joseph. Thirdly, Durable and extensive blessings: unto the utmost bound of the everlasting hills - Including all the products of the most fruitful hills, and lasting as long as they last. Of these blessings it is here said they shall be, so it is a promise; or, let them be, so it is a prayer, on the head of Joseph, to which let them be as a crown to adorn it, and a helmet to protect it.

Matthew Henry's Concise Commentary

49:22-27 The blessing of Joseph is very full. What Jacob says of him, is history as well as prophecy. Jacob reminds him of the difficulties and fiery darts of temptations he had formerly struggled through. His faith did not fail, but through his trials he bore all his burdens with firmness, and did not do anything unbecoming. All our strength for resisting temptations, and bearing afflictions, comes from God; his grace is sufficient. Joseph became the shepherd of Israel, to take care of his father and family; also the stone of Israel, their foundation and strong support. In this, as in many other things, Joseph was a remarkable type of the Good Shepherd, and tried Corner Stone of the whole church of God. Blessings are promised to Joseph's posterity, typical of the vast and everlasting blessings which come upon the spiritual seed of Christ. Jacob blessed all his sons, but especially Joseph, who was separated from his brethren. Not only separated in Egypt, but, possessing eminent dignity, and more devoted to God. Of Benjamin it is said, He shall ravin as a wolf. Jacob was guided in what he said by the Spirit of prophecy, and not by natural affection; else he would have spoken with more tenderness of his beloved son Benjamin. Concerning him he only foresees and foretells, that his posterity should be a warlike tribe, strong and daring, and that they should enrich themselves with the spoils of their enemies; that they should be active. Blessed Paul was of this tribe, Ro 11:1; Php 3:5; he, in the morning of his day, devoured the prey as a persecutor, but in the evening divided the spoils as a preacher; he shared the blessings of Judah's Lion, and assisted in his victories.