And it shall come to pass in that day, that the remnant of Israel, and such as have escaped of the house of Jacob, shall no more again lean upon him that smote them; but shall {p} lean upon the LORD, the Holy One of Israel, in truth.

(p) This is the end of God's plagues toward his, to bring them to him, and to forsake all trust in others.

Wesley's Notes

10:20 And such - Such Jews as shall be preserved from that sweeping Assyrian scourge. Stay - Shall no more trust to the Assyrians for help.

Scofield Reference Notes

[2] that day

"That day": often the equivalent of "the day of the Lord" Isa 2:10-22 Rev 19:11-21. The prophecy here passes from the general to the particular, from historic and fulfilled judgments upon Assyria to the final destruction of all Gentile world-power at the return of the Lord in glory. (See "Armageddon," Rev 16:14 19:21 "Times of the Gentiles," Lk 21:24 Rev 16:19, "The great tribulation," Ps 2:5 Rev 7:14, and See Scofield Note: "Isa 13:19"

Jamieson-Fausset-Brown Bible Commentary

20-22. The effect on the "remnant" (contrasted with the Assyrian remnant, Isa 10:19); namely, those who shall be left after the invasion of Sennacherib, will be a return from dependence on external idolatrous nations, as Assyria and Egypt (2Ki 18:21; 16:7-9), to the God of the theocracy; fulfilled in part in the pious Hezekiah's days; but from the future aspect under which Paul, in Ro 9:27, 28 (compare "short work" with "whole work," Isa 10:12, here), regards the whole prophecy, the "remnant," "who stay upon the Lord," probably will receive their fullest realization in the portion of Jews left after that Antichrist shall have been overthrown, who shall "return" unto the Lord (Isa 6:13; 7:3; Zec 12:9, 10; 14:2, 3; Zep 3:12).

Matthew Henry's Concise Commentary

10:20-34 By our afflictions we may learn not to make creatures our confidence. Those only can with comfort stay upon God, who return to him in truth, not in pretence and profession only. God will justly bring this wasting away on a provoking people, but will graciously set bounds to it. It is against the mind and will of God, that his people, whatever happens, should give way to fear. God's anger against his people is but for a moment; and when that is turned from us, we need not fear the fury of man. The rod with which he corrected his people, shall not only be laid aside, but thrown into the fire. To encourage God's people, the prophet puts them in mind of what God had formerly done against the enemies of his church. God's people shall be delivered from the Assyrians. Some think it looks to the deliverance of the Jews out of their captivity; and further yet, to the redemption of believers from the tyranny of sin and Satan. And this, because of the anointing; for his people Israel's sake, the believers among them that had received the unction of Divine grace. And for the sake of the Messiah, the Anointed of God. Here is, ver. 28-34, a prophetical description of Sennacherib's march towards Jerusalem, when he threatened to destroy that city. Then the Lord, in whom Hezekiah trusted, cut down his army like the hewing of a forest. Let us apply what is here written, to like matters in other ages of the church of Christ. Because of the anointing of our great Redeemer, the yoke of every antichrist must be broken from off his church: and if our souls partake of the unction of the Holy Spirit, complete and eternal deliverances will be secured to us.