Thus saith the LORD; Behold, I will raise up against Babylon, and against them that dwell in the midst of them that rise against me, a destroying {a} wind;

(a) The Medes and Persians who will destroy them as the wind does the chaff.

King James Translators' Notes

midst: Heb. heart

Jamieson-Fausset-Brown Bible Commentary

CHAPTER 51

Jer 51:1-64. Continuation of the Prophecy against Babylon Begun in the Fiftieth Chapter.

1. in the midst of them that rise . against me-literally, "in the heart" of them. Compare Ps 46:2, "the midst of the sea," Margin; Eze 27:4, "the heart of the seas"; Margin; Mt 12:40. In the center of the Chaldeans. "Against Me," because they persecute My people. The cabalistic mode of interpreting Hebrew words (by taking the letters in the inverse order of the alphabet, the last letter representing the first, and so on, Jer 25:26) would give the very word Chaldeans here; but the mystical method cannot be intended, as "Babylon" is plainly so called in the immediately preceding parallel clause.

wind-God needs not warlike weapons to "destroy" His foes; a wind or blast is sufficient; though, no doubt, the "wind" here is the invading host of Medes and Persians (Jer 4:11; 2Ki 19:7).

Matthew Henry's Concise Commentary

51:1-58 The particulars of this prophecy are dispersed and interwoven, and the same things left and returned to again. Babylon is abundant in treasures, yet neither her waters nor her wealth shall secure her. Destruction comes when they did not think of it. Wherever we are, in the greatest depths, at the greatest distances, we are to remember the Lord our God; and in the times of the greatest fears and hopes, it is most needful to remember the Lord. The feeling excited by Babylon's fall is the same with the New Testament Babylon, Re 18:9,19. The ruin of all who support idolatry, infidelity, and superstition, is needful for the revival of true godliness; and the threatening prophecies of Scripture yield comfort in this view. The great seat of antichristian tyranny, idolatry, and superstition, the persecutor of true Christians, is as certainly doomed to destruction as ancient Babylon. Then will vast multitudes mourn for sin, and seek the Lord. Then will the lost sheep of the house of Israel be brought back to the fold of the good Shepherd, and stray no more. And the exact fulfilment of these ancient prophecies encourages us to faith in all the promises and prophecies of the sacred Scriptures.