But from the beginning of the creation God made them male and female.

People's New Testament

10:2-11 The Pharisees came to him. Somewhere on the east of the Jordan, while on his way. For notes on this conversation about marriage and divorce, see Mt 19:3-13. Compare Lu 16:18.

Wesley's Notes

10:6 From the beginning of the creation - Therefore Moses in the first of Genesis gives us an account of things from the beginning of the creation. Does it not clearly follow, that there was no creation previous to that which Moses describes? God made them male and female - Therefore Adam did not at first contain both sexes in himself: but God made Adam, when first created, male only; and Eve female only. And this man and woman he joined together, in a state of innocence, as husband and wife.

Matthew Henry's Concise Commentary

10:1-12 Wherever Jesus was, the people flocked after him in crowds, and he taught them. Preaching was Christ's constant practice. He here shows that the reason why Moses' law allowed divorce, was such that they ought not to use the permission; it was only for the hardness of their hearts. God himself joined man and wife together; he has fitted them to be comforts and helps for each other. The bond which God has tied, is not to be lightly untied. Let those who are for putting away their wives consider what would become of themselves, if God should deal with them in like manner.