And about the ninth hour Jesus cried with a loud voice, saying, Eli, Eli, lama sabachthani? that is to say, My God, my God, why hast thou {o} forsaken me?

(o) That is, in this misery: And this crying out is a natural part of his humanity, which, even though it was void of sin, still felt the wrath of God, the wrath which is due to our sins.

People's New Testament

27:46 About the ninth hour. Three o'clock, after the Lord had been six hours on the cross. The cry that follows is from Ps 22:1.

Why hast thou forsaken me? These words can only express the idea that he was treading the wine-press alone. As he hung on the cross, made sin for us (2Co 5:21), he was left to struggle without a sense of his Father's presence.

My God, my God!. The cry shows that he still clung to the Father as his own.

Wesley's Notes

27:46 About the ninth hour, Jesus cried with a loud voice - Our Lord's great agony probably continued these three whole hours, at the conclusion of which be thus cried out, while he suffered from God himself what was unutterable. My God, my God, why hast thou forsaken me? - Our Lord hereby at once expresses his trust in God, and a most distressing sense of his letting loose the powers of darkness upon him, withdrawing the comfortable discoveries of his presence, and filling his soul with a terrible sense of the wrath due to the sins which he was bearing. Psalm 22:1.

Scofield Reference Notes

Margin why

Ps 22:3 gives the answer to this significant and terrible cry:

Matthew Henry's Concise Commentary

27:45-50 During the three hours which the darkness continued, Jesus was in agony, wrestling with the powers of darkness, and suffering his Father's displeasure against the sin of man, for which he was now making his soul an offering. Never were there three such hours since the day God created man upon the earth, never such a dark and awful scene; it was the turning point of that great affair, man's redemption and salvation. Jesus uttered a complaint from Ps 22:1. Hereby he teaches of what use the word of God is to direct us in prayer, and recommends the use of Scripture expressions in prayer. The believer may have tasted some drops of bitterness, but he can only form a very feeble idea of the greatness of Christ's sufferings. Yet, hence he learns something of the Saviour's love to sinners; hence he gets deeper conviction of the vileness and evil of sin, and of what he owes to Christ, who delivers him from the wrath to come. His enemies wickedly ridiculed his complaint. Many of the reproaches cast upon the word of God and the people of God, arise, as here, from gross mistakes. Christ, just before he expired, spake in his full strength, to show that his life was not forced from him, but was freely delivered into his Father's hands. He had strength to bid defiance to the powers of death: and to show that by the eternal Spirit he offered himself, being the Priest as well as the Sacrifice, he cried with a loud voice. Then he yielded up the ghost. The Son of God upon the cross, did die by the violence of the pain he was put to. His soul was separated from his body, and so his body was left really and truly dead. It was certain that Christ did die, for it was needful that he should die. He had undertaken to make himself an offering for sin, and he did it when he willingly gave up his life.