And the LORD God said, {x} Behold, the man is become as one of us, to know good and evil: and now, lest he put forth his hand, and {y} take also of the tree of life, and eat, and live for ever:

(x) By this derision by reproaches Adam's misery, into which he was fallen by ambition.

(y) Adam deprived of life, lost also the sign of it.

Wesley's Notes

3:22 Behold, the man is become as one of us, to know good and evil - See what he has got, what advantages, by eating forbidden fruit! This is said to humble them, and to bring them to a sense of their sin and folly, that seeing themselves thus wretchedly deceived by following the devil's counsel, they might henceforth pursue the happiness God offers, in the way he prescribes.

Jamieson-Fausset-Brown Bible Commentary

22. And God said, Behold, the man is become as one of us-not spoken in irony as is generally supposed, but in deep compassion. The words should be rendered, "Behold, what has become [by sin] of the man who was as one of us"! Formed, at first, in our image to know good and evil-how sad his condition now.

and now, lest he put forth his hand, and take also of the tree of life-This tree being a pledge of that immortal life with which obedience should be rewarded, man lost, on his fall, all claim to this tree; and therefore, that he might not eat of it or delude himself with the idea that eating of it would restore what he had forfeited, the Lord sent him forth from the garden.

Matthew Henry's Concise Commentary

3:22-24 God bid man go out; told him he should no longer occupy and enjoy that garden: but man liked the place, and was unwilling to leave it, therefore God made him go out. This signified the shutting out of him, and all his guilty race, from that communion with God, which was the bliss and glory of paradise. But man was only sent to till the ground out of which he was taken. He was sent to a place of toil, not to a place of torment. Our first parents were shut out from the privileges of their state of innocency, yet they were not left to despair. The way to the tree of life was shut. It was henceforward in vain for him and his to expect righteousness, life, and happiness, by the covenant of works; for the command of that covenant being broken, the curse of it is in full force: we are all undone, if we are judged by that covenant. God revealed this to Adam, not to drive him to despair, but to quicken him to look for life and happiness in the promised Seed, by whom a new and living way into the holiest is laid open for us.