{22} And the dragon was wroth with the woman, and went to make war with the remnant of her seed, which keep the commandments of God, and have the testimony of Jesus Christ.

(22) Being set on fire by this means, he began to be more mad, and because he perceived that his purpose against the Christian Church of the Jewish remnant was come to nothing, he resolved to fall on her seed, that is, the Church of the Gentiles, gathered by God and the holy members of the church. This is that other part, as is said in Re 12:13 in which the purpose of Satan is shown in Re 12:17 and his attempt, in Re 13:1.

People's New Testament

12:17 And the dragon was wroth with the woman. Waxed wroth (Revised Version). Was angry at his defeat. He continued the warfare by asking to destroy the woman's seed. I believe that this vision reveals the persecution of the true Church, first by Pagan, and then by Papal Rome, a persecution that results in the apparent disappearance of the true Church from the earth. Though not visible to the eye of the historian during this period, yet the true Church, fed of God, survives in the hearts of the hidden and persecuted saints. The period of her exile began about 533, in the reign of Justinian, and ends about the beginning of the nineteenth century. Before the end of the period, the Divine measure, the reed of the apostles, was used to measure the temple, altar and worshipers, and, as the result, over three-fourths of a century ago, the true Church began to appear as a visible body, once more in the world.

Jamieson-Fausset-Brown Bible Commentary

17. wroth with-Greek, "at."

went-Greek, "went away."

the remnant of her seed-distinct in some sense from the woman herself. Satan's first effort was to root out the Christian Church, so that there should be no visible profession of Christianity. Foiled in this, he wars (Re 11:7; 13:7) against the invisible Church, namely, "those who keep the commandments of God, and have the testimony of Jesus" (A, B, and C omit "Christ"). These are "the remnant," or rest of her seed, as distinguished from her seed, "the man-child" (Re 12:5), on one hand, and from mere professors on the other. The Church, in her beauty and unity (Israel at the head of Christendom, the whole forming one perfect Church), is now not manifested, but awaiting the manifestations of the sons of God at Christ's coming. Unable to destroy Christianity and the Church as a whole, Satan directs his enmity against true Christians, the elect remnant: the others he leaves unmolested.

Matthew Henry's Concise Commentary

12:12-17 The church and all her friends might well be called to praise God for deliverance from pagan persecution, though other troubles awaited her. The wilderness is a desolate place, and full of serpents and scorpions, uncomfortable and destitute of provisions; yet a place of safety, as well as where one might be alone. But being thus retired could not protect the woman. The flood of water is explained by many to mean the invasions of barbarians, by which the western empire was overwhelmed; for the heathen encouraged their attacks, in the hope of destroying Christianity. But ungodly men, for their worldly interests, protected the church amidst these tumults, and the overthrow of the empire did not help the cause of idolatry. Or, this may be meant of a flood of error, by which the church of God was in danger of being overwhelmed and carried away. The devil, defeated in his designs upon the church, turns his rage against persons and places. Being faithful to God and Christ, in doctrine, worship, and practice, exposes to the rage of Satan; and will do so till the last enemy shall be destroyed.