And Adam knew his wife again; and she bare a son, and called his name Seth: For God, said she, hath appointed me another seed instead of Abel, whom Cain slew.

Wesley's Notes

4:25 This is the first mention of Adam in the story of this chapter . No question the murder of Abel, and the impenitency and apostacy of Cain, were a very great grief to him and Eve, and the more because their own wickedness did now correct them, and their backsliding did reprove them. Their folly had given sin and death entrance into the world, and now they smarted by it, being by means thereof deprived of both their sons in one day, Gen 27:45. When parents are grieved by their children's wickedness, they should take occasion from thence to lament that corruption of nature which was derived from them, and which is the root of bitterness. But here we have that which was a relief to our first parents in their affliction, namely, God gave them to see the rebuilding of their family which was sorely shaken and weakened by that sad event. For, they saw their seed, another instead of Abel. And Adam called his name Seth - That is, Set, settled or placed, because in his seed mankind should continue to the end of time.

King James Translators' Notes

Seth: Heb. Sheth: that is Appointed, or, Put

Scofield Reference Notes

Margin Seth

i.e. Sheth = appointed.

Matthew Henry's Concise Commentary

4:25,26 Our first parents were comforted in their affliction by the birth of a son, whom they called Seth, that is, 'set,' 'settled,' or 'placed;' in his seed mankind should continue to the end of time, and from him the Messiah should descend. While Cain, the head of the apostacy, is made a wanderer, Seth, from whom the true church was to come, is one fixed. In Christ and his church is the only true settlement. Seth walked in the steps of his martyred brother Abel; he was a partaker of like precious faith in the righteousness of our God and Saviour Jesus Christ, and so became a fresh witness of the grace and influence of God the Holy Spirit. God gave Adam and Eve to see the revival of religion in their family. The worshippers of God began to do more in religion; some, by an open profession of true religion, protested against the wickedness of the world around. The worse others are, the better we should be, and the more zealous. Then began the distinction between professors and profane, which has been kept up ever since, and will be, while the world stands.