Persecute and destroy them in anger from under the heavens of the LORD.

Wesley's Notes

3:66 Persecute - Many passages of this nature which we meet with are prophecies, some of them may be both prophecies and prayers.

Jamieson-Fausset-Brown Bible Commentary

66. from under . heavens of . Lord-destroy them so that it may be seen everywhere under heaven that thou sittest above as Judge of the world.

Matthew Henry's Concise Commentary

3:55-66 Faith comes off conqueror, for in these verses the prophet concludes with some comfort. Prayer is the breath of the new man, drawing in the air of mercy in petitions, and returning it in praises; it proves and maintains the spiritual life. He silenced their fears, and quieted their spirits. Thou saidst, Fear not. This was the language of God's grace, by the witness of his Spirit with their spirits. And what are all our sorrows, compared with those of the Redeemer? He will deliver his people from every trouble, and revive his church from every persecution. He will save believers with everlasting salvation, while his enemies perish with everlasting destruction.